RESEARCH

CURRENT

Measuring the Dynamics of DNA Replication.

Dekker Group - University of Oxford

Development of a full toolset for the analysis of raw TIRF microscopy images of the eukaryotic replisome on flow-stretched DNA constructs.

Hardware interfacing and simulation tools for magnetic tweezer experiments into DNA dynamics.

Watch this space.

PUBLICATIONS

model capsid

Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures

Phys. Rev. Lett. 125.228101 (2020); First Author

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Developed an evolutionary algorithm, coupled with a molecular dynamics model for desiging nanoparticles optimised for cell entry. Identified design rules which govern successful passive cell membrane uptake.

model summary

Phase separation in the outer membrane of Escherichia coli

PNAS 118.44 (2021); Contributing Author

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Contributed by developing a machine learning model for automatically labelling pore in AFM images of E-coli.

UNPUBLISHED/IN REVIEW

collagen fibril identification

Guiding self assembly of coarse grained collagen mimetic molecules

Expanded upon work by Hafner et. al. by developing a new system for characterising collagen mimetic fibrils in simulation, and using evolutionary algorithms to drive their assembly.

This work made up the second half of my thesis and is currently being expanded upon for a future publication.

OTHER WORK

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Artificial Intelligence for Drug Discovery

Private Research - SyntheticGestalt

Developed large scale AI models to screen small molecule drug candidates for targeting and interrupting disease pathways.

Produced new augmented datasets for model training, and fine-tuned generative models for molecular design.

NET

Human Immunomodulation in Space

CoMPLEX - UCL

Development of novel experiments for investigation into immune recovery in space.

Preliminary study into modelling of transmission of sunlight in extraterrestrial environments.

NET

Characterising the Randomness of Rainforests

CoMPLEX - UCL

Network analysis of the BCI rainforest plot to detect communities.

Analysis of the traits of subcommunities as a proxy for detecting niches.

GODS

Using Genetic Algorithms to Design Nanoparticles

CoMPLEX - UCL

Developed a genetic algorithm to maximise cell membrane deformation by nanoparticles in simulations.

This short project ended up forming the backbone of my later PhD projects.